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Publications

QbD and PAT

  • Quality by control: Towards model predictive control of mammalian cell culture bioprocesses
    Sommeregger, W., Sissolak, B., Kandra, K., von Stosch, M., Mayer, M. & Striedner, G. (2017), Quality by control: Towards model predictive control of mammalian cell culture bioprocesses. Biotechnol. J., 12: 1600546. https://doi.org/10.1002/biot.201600546
  • Advances in monitoring and control of refolding kinetics combining PAT and modeling
    Pauk JN, Raju Palanisamy J, Kager J, Koczka K, Berghammer G, Herwig C, Veiter L. Advances in monitoring and control of refolding kinetics combining PAT and modeling. Appl Microbiol Biotechnol. 2021 Mar;105(6):2243-2260.https://doi.org/10.1007/s00253-021-11151-y
  • Oxygen uptake rate soft-sensing via dynamic kl a computation: Cell volume and metabolic transition prediction in mammalian bioprocesses
    Pappenreiter, M., Sissolak, B., & Sommeregger, W. (2019). Oxygen Uptake Rate Soft-Sensing via Dynamic k L a Computation : Cell Volume and Metabolic Transition Prediction in Mammalian Bioprocesses. 7(August), 1–16. https://doi.org/10.3389/fbioe.2019.00195

Bio-Process Engineering

  • Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process development
    Sissolak B., Lingg N., Sommeregger W., Striedner G. & Vorauer-Uhl K., Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process development, Journal of Industrial Microbiology and Biotechnology, Volume 46, Issue 8, 1 August 2019, Pages 1167–1178, https://doi.org/10.1007/s10295-019-02202-5
  • Quantification of glycated IgG in CHO supernatants: A practical approach
    Lhota, G., Sissolak, B., Striedner, G., Sommeregger, W., & Vorauer-Uhl, K. (2021). Quantification of glycated IgG in CHO supernatants: A practical approach. Biotechnology progress, 37(3), e3124. Advance online publication. https://doi.org/10.1002/btpr.3124
  • Lectin bio-layer interferometry for assessing product quality of Fc- glycosylated immunoglobulin G
    Wallner, J, Sissolak, B, Sommeregger, W, Lingg, N, Striedner, G & Vorauer-Uhl, K. Lectin bio-layer interferometry for assessing product quality of Fc- glycosylated immunoglobulin G. Biotechnol Progress. 2019; 35:e2864. https://doi.org/10.1002/btpr.2864
  • Application of the Bradford Assay for Cell Lysis Quantification: Residual Protein Content in Cell Culture Supernatants
    Sissolak, B., Zabik, C., Saric, N., Sommeregger, W., Vorauer-Uhl, K. & Striedner, G. (2019), Application of the Bradford Assay for Cell Lysis Quantification: Residual Protein Content in Cell Culture Supernatants. Biotechnol. J., 14: 1800714. https://doi.org/10.1002/biot.201800714

Process & Economic Modelling

  • Water related impact of energy: Cost and carbon footprint analysis of water for biopharmaceuticals from tap to waste
    Cataldo, A. L., Sissolak, B., Metzger, K., Budzinski, K., Shirokizawa, O., Luchner, M., Jungbauer, A., & Satzer, P. (2020). Water related impact of energy: Cost and carbon footprint analysis of water for biopharmaceuticals from tap to waste. Chemical Engineering Science: X, 8, 100083. https://doi.org/10.1016/j.cesx.2020.100083
  • The shortcomings of accurate rate estimations in cultivation processes and a solution for precise and robust process modeling
    Bayer, B., Sissolak, B., Duerkop, M., Stosch, M. Von, & Striedner, G. (2019). The shortcomings of accurate rate estimations in cultivation processes and a solution for precise and robust process modeling. Bioprocess and Biosystems Engineering. https://doi.org/10.1007/s00449-019-02214-6
  • Impact of failure rates, lot definitions and scheduling of upstream processes on the productivity of continuous integrated bioprocesses
    Satzer, P., Komuczki, D., Pappenreiter, M., Cataldo, A.L., Sissolak, B. & Jungbauer, A. (2021), Impact of failure rates, lot definitions and scheduling of upstream processes on the productivity of continuous integrated bioprocesses. J Chem Technol Biotechnol. https://doi.org/10.1002/jctb.6648
  • Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments 
    Bayer B, Duerkop M, Striedner G and Sissolak B (2021) Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments. Front. Bioeng. Biotechnol. 9:740215. https://doi.org/10.3389/fbioe.2021.740215

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